Cadmus will help you filter them thanks to a relevance filter and will show you the most important ones just not to get you in a mess.
The filter is based on answers and retweets. By this way, you'll see those that are thought to be more important first, and then, the rest.
It offers many ways to customize the tweet list. Receive news in different ways according to different filters and be up to date.
Don't miss anything but don't get in amessof irrelevant tweets, Cadmus will help you. We could say it's your Twitter assistant.